Sodium valproate vs phenytoin in status epilepticus: a pilot study.
نویسندگان
چکیده
Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.
منابع مشابه
The efficacy of intravenous sodium valproate and phenytoin as the first-line treatment in status epilepticus: a comparison study
BACKGROUND Status epilepticus (SE) is a serious neurological condition and requires prompt treatment. Sodium valproate has been used to treat SE successfully but its role as the first-line antiepileptic drug (AED) is still controversial. This study evaluated the efficacy of intravenous sodium valproate to determine if it is non-inferior to intravenous phenytoin in SE treatment. METHODS Patien...
متن کاملCan intravenous sodium valproate be the first-line treatment in status epilepticus? A comparison study with intravenous phenytoin
Background: Status epilepticus (SE) is a serious neurological condition and requires prompt treatment. Sodium valproate has been used to treat SE successfully but its role as the first-line antiepileptic drug (AED) is still controversial. We aimed to compare the efficacy of intravenous sodium valproate and phenytoin head-to-head as the firstline AED treatment in SE. Methods: We enrolled patient...
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متن کاملThe relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: A meta-analysis of published studies
PURPOSE Systematic evaluation of published evidence-base of the efficacy of five antiepileptic drugs - lacosamide, levetiracetam, valproate, phenytoin and phenobarbital - in convulsive benzodiazepine-resistant status epilepticus. METHODS Data sources included electronic databases, personal communication, and back tracing of references in pertinent studies. These were prospective and retrospec...
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ورودعنوان ژورنال:
- Neurology
دوره 67 2 شماره
صفحات -
تاریخ انتشار 2006